Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism

  title={Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism},
  author={Young-Seon Kim and Yoon-Mi Lee and Taek-In Oh and D. H. Shin and G. Kim and S. Kan and Hyeji Kang and J. Kim and Byeong Mo Kim and Woo jong Yim and Ji-Hong Lim},
  journal={International Journal of Molecular Sciences},
  • Young-Seon Kim, Yoon-Mi Lee, +8 authors Ji-Hong Lim
  • Published 2018
  • Chemistry, Medicine
  • International Journal of Molecular Sciences
  • Reduced therapeutic efficacy of sorafenib, a first-generation multikinase inhibitor, is often observed during the treatment of advanced hepatocellular carcinoma (HCC). Emodin is an active component of Chinese herbs, and is effective against leukemia, lung cancer, colon cancer, pancreatic cancer, and HCC; however, the sensitizing effect of emodin on sorafenib-based HCC therapy has not been evaluated. Here, we demonstrate that emodin significantly improved the anti-cancer effect of sorafenib in… CONTINUE READING
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