Emodin Ameliorates Glucose-Induced Morphologic Abnormalities and Synthesis of Transforming Growth Factor β1 and Fibronectin by Human Peritoneal Mesothelial Cells

@article{Yung2001EmodinAG,
  title={Emodin Ameliorates Glucose-Induced Morphologic Abnormalities and Synthesis of Transforming Growth Factor β1 and Fibronectin by Human Peritoneal Mesothelial Cells},
  author={S. Yung and Z. Liu and K. Lai and L. Li and T. Chan},
  journal={Peritoneal Dialysis International},
  year={2001},
  volume={21},
  pages={41 - 47}
}
  • S. Yung, Z. Liu, +2 authors T. Chan
  • Published 2001
  • Medicine
  • Peritoneal Dialysis International
  • ♦ Objective Excessive synthesis and deposition of matrix proteins by peritoneal mesothelial cells can lead to structural and functional changes in the peritoneal membrane, jeopardizing the long-term efficacy of peritoneal dialysis (PD). Prolonged exposure to high glucose concentrations in PD fluid has been implicated as a major stimulus to matrix accumulation, through the induction of transforming growth factor β1 (TGFβ 1). This study investigated the effect of emodin (3-methyl-1,6,8… CONTINUE READING
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