Emodin, a natural product, selectively inhibits 11β‐hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet‐induced obese mice

@article{Feng2010EmodinAN,
  title={Emodin, a natural product, selectively inhibits 11β‐hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet‐induced obese mice},
  author={Y. Feng and Su-Ling Huang and W. Dou and Song Zhang and Jun-hua Chen and Y. Shen and J. Shen and Y. Leng},
  journal={British Journal of Pharmacology},
  year={2010},
  volume={161}
}
  • Y. Feng, Su-Ling Huang, +5 authors Y. Leng
  • Published 2010
  • Biology, Medicine
  • British Journal of Pharmacology
  • BACKGROUND AND PURPOSE 11β‐Hydroxysteroid dehydrogenase type 1 (11β‐HSD1) is an attractive therapeutic target of type 2 diabetes and metabolic syndrome. Emodin, a natural product and active ingredient of various Chinese herbs, has been demonstrated to possess multiple biological activities. Here, we investigated the effects of emodin on 11β‐HSD1 and its ability to ameliorate metabolic disorders in diet‐induced obese (DIO) mice. 
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