Emission Tuning of Fluorescent Kinase Inhibitors: Conjugation Length and Substituent Effects

@inproceedings{Dhuguru2014EmissionTO,
  title={Emission Tuning of Fluorescent
Kinase Inhibitors:
Conjugation Length and Substituent Effects},
  author={Jyothi Dhuguru and Wenjun Liu and Walter G. Gonzalez and W. Michael Babinchak and Jaroslava Miksovska and Ralf Landgraf and James N Wilson},
  booktitle={The Journal of organic chemistry},
  year={2014}
}
Fluorescent N-phenyl-4-aminoquinazoline probes targeting the ATP-binding pocket of the ERBB family of receptor tyrosine kinases are reported. Extension of the aromatic quinazoline core with fluorophore "arms" through substitution at the 6- position of the quinazoline core with phenyl, styryl, and phenylbutadienyl moieties was predicted by means of TD-DFT… CONTINUE READING