Emile Zuckerkandl, Linus Pauling, and the Molecular Evolutionary Clock, 1959–1965

  title={Emile Zuckerkandl, Linus Pauling, and the Molecular Evolutionary Clock, 1959–1965},
  author={Gregory J. Morgan},
  journal={Journal of the History of Biology},
Emile Zuckerkandl et Linus Pauling ont demontre que le taux d'evolution des proteines est approximativement constant au cours du temps 

Rate variation during molecular evolution: creationism and the cytochrome c molecular clock

This paper traces some of the history of extensive research into the topic of rate heterogeneity in cytochrome c including data from cy tochrome c pseudogenes to resolve the apparent anomaly of human cyto chrome c differs from that of an alligator but differs by 14 amino acids from a much more closely related primate.

Molecular Clock: An Anti-neo-Darwinian Legacy

The high evolutionary rate estimated from hemoglo-bin and other proteins was a key to development of the neutral theory by Motoo Kimura, rather than, as some-times asserted, the large extent of electrophoreticallyobserved polymorphism.

Molecular clocks: four decades of evolution

During the past four decades, the molecular-clock hypothesis has provided an invaluable tool for building evolutionary timescales, and has served as a null model for testing evolutionary and mutation

Three Perspectives on Neutrality and Drift in Molecular Evolution

Three contrasting cases of the use of neutrality and drift in molecular evolution are offered: neutrality is assumed as a simplest case for modeling, concepts of drift and neutrality are developed within the context of population genetics testing and the development of the molecular clock.

Richard Dickerson, Molecular Clocks, and Rates of Protein Evolution

The first analysis in which the rates of evolution of many proteins were compared, and the differences were interpreted in the light of their function was described, and its impact on the field of Molecular Evolution is reflected.

Waiting for Sequences: Morris Goodman, Immunodiffusion Experiments, and the Origins of Molecular Anthropology

  • J. Hagen
  • Biology
    Journal of the history of biology
  • 2010
During the early 1960s, Morris Goodman used a variety of immunological tests to demonstrate the very close genetic relationships among humans, chimpanzees, and gorillas and challenged the widely accepted taxonomic classification.

Evolutionary Approaches to Sequence Alignment

This paper presents a probabilistic procedure that can be used to estimate the ages of individual cells by analyzing the sequences of amino acids or nucleotides in a collection of cells.

From genomes to post-processing of Bayesian inference of phylogeny

This research presents a new probabilistic procedure called “spot-spot dismembering” that allows for precise and efficient counts of the number of mitochondria in a single cell.

Bayesian molecular clock dating of species divergences in the genomics era

The molecular clock hypothesis has become a powerful tool in evolutionary biology, making it possible to use molecular sequences to estimate the geological ages of species divergence events and to estimate a timescale for life on Earth.

The Molecular Clock and Evolutionary Rates Across the Tree of Life

  • S. Ho
  • Biology
    The Molecular Evolutionary Clock
  • 2020
This chapter describes the origins of the molecular clock hypothesis and the mixture of evidence that emerged throughout the 1970s and 1980s, including the discovery of departures from clocklike evolution in proteins and DNA.