Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins.

  title={Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins.},
  author={Julie D. R. Reimann and Bryan E Gardner and Florence Margottin-Goguet and Peter Kent Jackson},
  journal={Genes & development},
  volume={15 24},
The anaphase-promoting complex/cyclosome (APC) ubiquitin ligase is activated by Cdc20 and Cdh1 and inhibited by Mad2 and the spindle assembly checkpoint complex, Mad2B, and the early mitotic inhibitor Emi1. Mad2 inhibits APC(Cdc20), whereas Mad2B preferentially inhibits APC(Cdh1). We have examined the mechanism of APC inhibition by Emi1 and find that unlike Mad2 proteins, Emi1 binds and inhibits both APC(Cdh1) and APC(Cdc20). Also unlike Mad2, Emi1 stabilizes cyclin A in the embryo and requires… CONTINUE READING
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