Emetic action of the prostanoid TP receptor agonist, U46619, in Suncus murinus (house musk shrew).

@article{Kan2003EmeticAO,
  title={Emetic action of the prostanoid TP receptor agonist, U46619, in Suncus murinus (house musk shrew).},
  author={Kelvin K. Kan and R. L. Jones and Man-P Ngan and John A Rudd and Michael Wai},
  journal={European journal of pharmacology},
  year={2003},
  volume={482 1-3},
  pages={297-304}
}
The emetic action of the prostanoid TP receptor agonist, 11alpha,9alpha-epoxymethano-15S-hydroxyprosta-5Z,13E-dienoic acid (U46619; 300 microg/kg, i.p.), was investigated in Suncus murinus. The emetic response was reduced by 76% following bilateral abdominal vagotomy (P<0.001) and by reserpine (5 mg/kg, i.p., 24 h pretreatment; P<0.05) but U46619 administered i.c.v. (30-300 ng) was not emetic, suggesting a peripheral mechanism involving monoamines. However, fenfluramine (5 mg/kg, repeated… CONTINUE READING