Emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs

  title={Emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs},
  author={Brenda Costall and Annette M. Domeney and Robert J. Naylor and F. David Tattersall},

Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT3 receptor antagonists

It is revealed that the efficacy of ondansetron is similar against low and high doses of cisplatin, and 5-HT3 receptor antagonists have a similar efficacy during acute and delayedEmesis, which provides a novel insight into the pharmacology of delayed emesis in the ferret.

Serotonin 5-HT3 receptor antagonists prevent cisplatin-induced emesis in Cryptotis parva: a new experimental model of emesis

  • N. Darmani
  • Biology
    Journal of Neural Transmission
  • 1998
As with other established experimental animal emesis models, the present data indicate that cisplatin causes emesis by activating 5-HT3 receptors indirectly via release of5-HT.

The Actions of Fenfluramine and Interaction with 5‐HT3 Receptor‐Antagonists to Inhibit Emesis in the Ferret

It is considered that an action of the racemate on presynaptic 5‐HT/catecholaminergic systems to reduce neurotransmitter release may enhance the action of certain 5‐ HT3 receptor antagonists in controlling emesis induced by cisplatin.



Antagonism of cisplatin induced emesis in the dog.

Metoclopramide was found to be the most effective antagonsit of Cisplatin emesis in the dog while haloperidol and chlorpromazine offered a less complete protection.

Cisplatin-induced emesis in the Ferret: a new animal model.

The ferret was evaluated for its potential use in testing drugs for emetic and antiemetic activity and an acute emetic response to apomorphine indicated that the ferret can respond to emetic stimuli and suggested that it has an emetic chemoreceptor trigger zone.

Metoclopramide. A review of antiemetic trials.

Uncontrolled observations of continued metoclopramide treatment during subsequent courses of cisplatin suggest preservation of antiemetic efficacy, and preliminary results of studies of metoclobramide in non-cisplatin-containing regimens suggest benefit.

Inhibition of cisplatin‐induced vomiting by selective 5‐hydroxytryptamine M‐receptor antagonism

MDL 72222, the selective 5‐hydroxytryptamine (5‐HT) M‐receptor antagonist, prevented or reduced cisplatin‐induced emesis in ferrets. It is suggested that cisplatin‐induced, and possibly other

Effects of benzodiazepines on central serotonergic mechanisms.

Results parallel findings in the conflict test which indicate that the depressant action of oxazepam rapidly undergoes tolerance, whereas the anxiety-reducing action is maintained over repeated doses, suggesting that the drugs actually act indirectly to reduce serotonin activity.

5‐Hydroxytryptamine receptor antagonism by metoclopramide and ICS 205–930 in the guinea‐pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying in‐vivo

The abilities of metoclopramide, MDL 72222 and ICS 205–930 to enhance stomach muscle contraction processes and to facilitate gastric emptying may be the consequence of 5‐hydroxytryptamine receptor antagonism.

The acute effects of oral (--)-tryptophan in human subjects.

1 The psychotropic effects of a single oral dose of (--)-tryptophan (5 g) in human volunteers were investigated using a series of physiological and psychological tests. 2 Self-ratings of mood showed