Emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs

@article{Costall1987EmesisIB,
  title={Emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs},
  author={Brenda Costall and Annette M. Domeney and Robert J. Naylor and F. David Tattersall},
  journal={Neuropharmacology},
  year={1987},
  volume={26},
  pages={1321-1326}
}

Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT3 receptor antagonists

It is revealed that the efficacy of ondansetron is similar against low and high doses of cisplatin, and 5-HT3 receptor antagonists have a similar efficacy during acute and delayedEmesis, which provides a novel insight into the pharmacology of delayed emesis in the ferret.

Serotonin 5-HT3 receptor antagonists prevent cisplatin-induced emesis in Cryptotis parva: a new experimental model of emesis

  • N. Darmani
  • Biology
    Journal of Neural Transmission
  • 1998
As with other established experimental animal emesis models, the present data indicate that cisplatin causes emesis by activating 5-HT3 receptors indirectly via release of5-HT.

The Actions of Fenfluramine and Interaction with 5‐HT3 Receptor‐Antagonists to Inhibit Emesis in the Ferret

It is considered that an action of the racemate on presynaptic 5‐HT/catecholaminergic systems to reduce neurotransmitter release may enhance the action of certain 5‐ HT3 receptor antagonists in controlling emesis induced by cisplatin.
...

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