Emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs

  title={Emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs},
  author={Brenda Costall and Annette M. Domeney and Robert J. Naylor and F. David Tattersall},
The intravenous injection of cisplatin in the ferret caused a consistent emetic (vomiting/retching) response. Emesis induced by cisplatin was abolished by the 5-hydroxytryptamine (5-HT) M-receptor antagonists ICS205-930, zacopride, dazopride and metoclopramide. The neuroleptic agents haloperidol, fluphenazine, domperidone, sulpiride and tiapride also antagonized emesis induced by cisplatin but only a proportion of the animals were completely protected and diazepam and prednisolone only reduced… Expand
The effects of 5-HT3 receptor antagonists on cisplatin-induced emesis in the pigeon.
The intrinsic emetic effects of 5-HT3 receptor antagonists provide pharmacological evidence of species differences in the properties of 5.HT3 receptors, as well as protective effects against cisplatin emesis, are concluded. Expand
A dual effect of some 5-HT3 receptor antagonists on cisplatin-induced emesis in the pigeon.
It is concluded that the intrinsic emetic effects of 5-HT3 receptor antagonists in the pigeon provide pharmacological evidence of species differences in the properties of 5 HT3 receptors. Expand
Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT3 receptor antagonists
It is revealed that the efficacy of ondansetron is similar against low and high doses of cisplatin, and 5-HT3 receptor antagonists have a similar efficacy during acute and delayedEmesis, which provides a novel insight into the pharmacology of delayed emesis in the ferret. Expand
Serotonin 5-HT3 receptor antagonists prevent cisplatin-induced emesis in Cryptotis parva: a new experimental model of emesis
  • N. Darmani
  • Biology, Medicine
  • Journal of Neural Transmission
  • 1998
As with other established experimental animal emesis models, the present data indicate that cisplatin causes emesis by activating 5-HT3 receptors indirectly via release of5-HT. Expand
Emesis induced in domestic pigs: a new experimental tool for detection of antiemetic drugs and for evaluation of emetogenic potential of new anticancer agents.
The domestic pig was used to develop a new model for evaluating the emetogenic potential of anticancer drugs and determining the antiemetic activity of drugs, and it was found that the domestic pig is suitable to detect the emetic potential of chemotherapeutic agents. Expand
Effects of N-methyl-d-aspartate receptor antagonists on cisplatin-induced emesis in the Ferret
It is concluded that NMDA receptor antagonists may afford protection against cisplatin-induced emesis but the specificity of this effect is uncertain since it may relate to general CNS depression. Expand
Inhibition of cisplatin-induced emesis in ferrets by the non-NMDA receptor antagonists NBQX and CNQX
It is concluded that non-NMDA antagonists effectively inhibit cisplatin-induced emesis in ferrets and are potential antiemetic compounds, alone or in combination with 5-HT3 antagonists or other more conventional drugs of choice. Expand
Blockade of 5-Hydroxytryptamine3 receptors prevents cisplatin-induced but not motion- or xylazine-induced emesis in the cat
  • J. Lucot
  • Medicine
  • Pharmacology Biochemistry and Behavior
  • 1989
This result verifies other work which found 5-hydroxytryptamine3 antagonists to be effective in preventing emesis elicited by cancer chemotherapeutic treatments, however, there is no evidence that they are effective in other syndromes, such as motion sickness and xylazine-induced emesis. Expand
The Actions of Fenfluramine and Interaction with 5‐HT3 Receptor‐Antagonists to Inhibit Emesis in the Ferret
It is considered that an action of the racemate on presynaptic 5‐HT/catecholaminergic systems to reduce neurotransmitter release may enhance the action of certain 5‐ HT3 receptor antagonists in controlling emesis induced by cisplatin. Expand
The effects of different antiemetic agents on morphine-induced emesis in ferrets.
The morphine ferret model may be useful for evaluating compounds having the potential for preventing and treating postoperative vomiting and the significant reduction of morphine-induced emesis in the ferret by ondansetron, metoclopramide and droperidol is consistent with the reduction of postoperative emesis by these compounds when morphine was a component of the anesthetic regimen. Expand


Antagonism of cisplatin induced emesis in the dog.
Metoclopramide was found to be the most effective antagonsit of Cisplatin emesis in the dog while haloperidol and chlorpromazine offered a less complete protection. Expand
Cisplatin-induced emesis in the Ferret: a new animal model.
The ferret was evaluated for its potential use in testing drugs for emetic and antiemetic activity and an acute emetic response to apomorphine indicated that the ferret can respond to emetic stimuli and suggested that it has an emetic chemoreceptor trigger zone. Expand
5-hydroxytryptamine m-receptor antagonism to prevent cisplatin-induced emesis
It is concluded that the potent action of ICS 205-930 against cisplatin-induced emesis is the consequence of a 5-hydroxytryptamine M-receptor antagonism which may also contribute to the antiemetic action of metoclopramide. Expand
Metoclopramide. A review of antiemetic trials.
Uncontrolled observations of continued metoclopramide treatment during subsequent courses of cisplatin suggest preservation of antiemetic efficacy, and preliminary results of studies of metoclobramide in non-cisplatin-containing regimens suggest benefit. Expand
Inhibition of cisplatin‐induced vomiting by selective 5‐hydroxytryptamine M‐receptor antagonism
MDL 72222, the selective 5‐hydroxytryptamine (5‐HT) M‐receptor antagonist, prevented or reduced cisplatin‐induced emesis in ferrets. It is suggested that cisplatin‐induced, and possibly otherExpand
Effects of benzodiazepines on central serotonergic mechanisms.
Results parallel findings in the conflict test which indicate that the depressant action of oxazepam rapidly undergoes tolerance, whereas the anxiety-reducing action is maintained over repeated doses, suggesting that the drugs actually act indirectly to reduce serotonin activity. Expand
Gastrointestinal motor correlates of vomiting in the dog: quantification and characterization as an independent phenomenon.
The results suggest that the vomiting center may consist of two functionally distinct parts that are activated sequentially: one controlling the gastrointestinal responses and the other the somatomotor responses. Expand
5‐Hydroxytryptamine receptor antagonism by metoclopramide and ICS 205–930 in the guinea‐pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying in‐vivo
The abilities of metoclopramide, MDL 72222 and ICS 205–930 to enhance stomach muscle contraction processes and to facilitate gastric emptying may be the consequence of 5‐hydroxytryptamine receptor antagonism. Expand
Blockade of neuronal tryptamine receptors by metoclopramide.
The results indicate that metoclopramide is a potent, surmountable and selective antagonist of tryptamine receptors on rabbit cardiac sympathetic nerves. Expand
The acute effects of oral (--)-tryptophan in human subjects.
1 The psychotropic effects of a single oral dose of (--)-tryptophan (5 g) in human volunteers were investigated using a series of physiological and psychological tests. 2 Self-ratings of mood showedExpand