Emerging viruses: why they are not jacks of all trades?
@article{Bedhomme2015EmergingVW, title={Emerging viruses: why they are not jacks of all trades?}, author={St{\'e}phanie Bedhomme and Julia Hillung and Santiago F. Elena}, journal={Current opinion in virology}, year={2015}, volume={10}, pages={ 1-6 } }
Figures from this paper
42 Citations
Evolution and ecology of plant viruses
- Environmental Science, BiologyNature Reviews Microbiology
- 2019
This Review focuses on the origins of plant viruses and the evolution of interactions between these viruses and both their hosts and transmission vectors, and identifies currently unknown aspects of plant virus ecology and evolution that should be resolvable in the near future through viral metagenomics.
Analysis of Fitness Trade-Offs in the Host Range Expansion of an RNA Virus, Tobacco Mild Green Mosaic Virus
- BiologyJournal of Virology
- 2018
Comparing the performance of isolates of tobacco mild green mosaic virus from its reservoir host, Nicotiana glauca, and its new host, pepper, shows that acquisition of a new host was not followed by adaptation to it but was associated with a fitness loss in the original host.
Evolutionary ecology of virus emergence
- BiologyAnnals of the New York Academy of Sciences
- 2017
It is argued that, while virus acquisition of the ability to infect new hosts is not difficult, limited evolutionary trajectories to sustained virus between‐host transmission and the combined effects of mutational meltdown, bottlenecking, demographic stochasticity, density dependence, and genetic erosion in ecological sinks limit most emergence events to dead‐end spillover infections.
Local adaptation of plant viruses: lessons from experimental evolution
- BiologyMolecular ecology
- 2017
At the genomic level, these studies show pervasive convergent molecular evolution, suggesting that the number of accessible molecular pathways leading to adaptation to novel hosts is limited.
The phylogenomics of evolving virus virulence
- BiologyNature Reviews Genetics
- 2018
How largely disparate research fields — theoretical modelling of virulence evolution and experimental dissection of genetic virulence determinants in laboratory model systems — can be bridged by considering real genomic data of viral evolution in a phylogenetic context is discussed.
Defects in plant immunity modulate the rates and patterns of RNA virus evolution
- BiologybioRxiv
- 2020
When all evolved TuMV lineages were tested for fitness in all plant genotypes used in the experiments, it was found that the infection matrix was significantly nested, suggesting the evolution of generalist viruses selected by the most restrictive mutant genotypes.
Ecological Complexity in Plant Virus Host Range Evolution.
- Environmental Science, BiologyAdvances in virus research
- 2018
Evolution of plant-virus interactions: host range and virus emergence.
- BiologyCurrent opinion in virology
- 2019
The population genetics of pleiotropy, and the evolution of collateral resistance and sensitivity in bacteria
- Biology
- 2020
This work derives simple statistics of the JDFE that predict the expected slope, variance and co-variance of non-home fitness trajectories of Escherichia coli knock-out collection in the presence of antibiotics and provides simple theoretically grounded guidelines for designing robust sequential drug protocols.
References
SHOWING 1-10 OF 52 REFERENCES
What limits the evolutionary emergence of pathogens?
- BiologyPhilosophical Transactions of the Royal Society B: Biological Sciences
- 2013
Different theoretical perspectives yield important insights into optimal surveillance and intervention strategies, which should aim for a reduction in the emergence (and re-emergence) of infectious diseases.
The pleiotropic cost of host-specialization in Tobacco etch potyvirus.
- BiologyInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- 2008
The Evolutionary Genetics of Emerging Viruses
- Biology
- 2009
Although RNA viruses are characterized by their mutation rates, these rates may not be high enough to allow the onset of quasispecies dynamics, in which natural selection acts on the viral population as a whole.
The evolutionary genetics of emerging plant RNA viruses.
- BiologyMolecular plant-microbe interactions : MPMI
- 2011
The present review puts emergence of plant RNA viruses into the framework of evolutionary genetics, stressing that viral emergence begins with a stochastic process that involves the transmission of a preexisting viral strain into a new host species, followed by adaptation to the new host.
Multihost experimental evolution of a plant RNA virus reveals local adaptation and host-specific mutations.
- BiologyMolecular biology and evolution
- 2012
A pattern of local adaptation, characterized by a higher infectivity and virulence on host(s) encountered during the experimental evolution was found and it is confirmed that this classical theoretical prediction lacks empirical support.
Effect of Host Species on the Distribution of Mutational Fitness Effects for an RNA Virus
- BiologyPLoS genetics
- 2011
Describing the DMFE for a collection of twenty single-nucleotide substitution mutants of Tobacco etch potyvirus across a set of eight host environments suggests that TEV may easily broaden its host range and improve fitness in new hosts, and that knowledge about theDMFE in the natural host does not allow for making predictions about its properties in an alternative host.
Pleiotropic Costs of Niche Expansion in the RNA Bacteriophage Φ6
- BiologyGenetics
- 2006
The evolution of expanded host range (generalism) in the RNA virus Φ6 is investigated, an experimental model system allowing adaptive mutations to be readily identified and an epigenetic cost of generalism that occurs when phage transition between host types is identified.
Epistasis between mutations is host-dependent for an RNA virus
- BiologyBiology Letters
- 2013
Understanding the effect of host species in the sign and magnitude of epistasis will provide insights into the evolutionary ecology of infectious diseases and the predictability of viral emergence.
Fitness Ranking of Individual Mutants Drives Patterns of Epistatic Interactions in HIV-1
- BiologyPloS one
- 2011
A thorough analysis of a classical AZT-resistance pathway of HIV-1 variants by fitness measurements in single round infection assays covering physiological drug concentrations ex vivo suggests that epistasis might be inefficient as a buffering mechanism for fitness losses in vivo.
Genotypic but not phenotypic historical contingency revealed by viral experimental evolution
- BiologyBMC Evolutionary Biology
- 2012
The present experiment reinforces the idea that the answer to the question “How important is historical contingency in evolution” strongly depends on the level of integration of the traits studied, and implies that viruses are not easily trapped into suboptimal phenotypes and that (re)emergence is not evolutionarily constrained.