Emerging treatment strategies in recurrent platinum-sensitive ovarian cancer: focus on trabectedin.

@article{Poveda2014EmergingTS,
  title={Emerging treatment strategies in recurrent platinum-sensitive ovarian cancer: focus on trabectedin.},
  author={Andr{\'e}s M Poveda and Isabelle Laure Ray-Coquard and Ignacio Romero and J{\'o}se Antonio L{\'o}pez-Guerrero and Nicoletta Colombo},
  journal={Cancer treatment reviews},
  year={2014},
  volume={40 3},
  pages={366-75}
}
Ovarian cancer (OC) is the leading cause of death from gynecological malignancies. In spite of high response rates to the standard front-line treatment for advanced disease with cytoreductive surgical debulking, followed by platinum/taxane-based chemotherapy, most patients eventually relapse developing drug-resistant disease. Owing to the molecular heterogeneity, genetic instability and mutagenicity of OC, increases in survival might be achieved by translating recent insights at the morpho… CONTINUE READING

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