Emerging treatment options for the treatment of neuroblastoma: potential role of perifosine

@inproceedings{Sun2012EmergingTO,
  title={Emerging treatment options for the treatment of neuroblastoma: potential role of perifosine},
  author={Weili Sun and Shakeel Modak},
  booktitle={OncoTargets and therapy},
  year={2012}
}
Achieving a cure for high-risk neuroblastoma, the most common extracranial solid tumor in children, remains a formidable task despite the recent addition of antibody-mediated anti-GD2 immunotherapy to established multimodality therapy. The PI3K/Akt pathway is a pivotal signaling pathway utilized by a plethora of receptor tyrosine kinases that contribute to the aggressive phenotype of high-risk neuroblastoma. Akt is aberrantly activated in high-risk neuroblastoma and is therefore an attractive… CONTINUE READING
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