Emerging transporters of clinical importance: an update from the International Transporter Consortium.

@article{Hillgren2013EmergingTO,
  title={Emerging transporters of clinical importance: an update from the International Transporter Consortium.},
  author={Kathleen M. Hillgren and Dietrich Keppler and Arik A. Zur and Kathy Giacomini and Bruno Stieger and Carol E. Cass and Lei Zhang},
  journal={Clinical pharmacology and therapeutics},
  year={2013},
  volume={94 1},
  pages={
          52-63
        }
}
The International Transporter Consortium (ITC) has recently described seven transporters of particular relevance to drug development. Based on the second ITC transporter workshop in 2012, we have identified additional transporters of emerging importance in pharmacokinetics, interference of drugs with transport of endogenous compounds, and drug-drug interactions (DDIs) in humans. The multidrug and toxin extrusion proteins (MATEs, gene symbol SLC47A) mediate excretion of organic cations into bile… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 155 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 92 extracted citations

Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs.

Drug metabolism and disposition: the biological fate of chemicals • 2016
View 7 Excerpts
Method Support
Highly Influenced

155 Citations

02040'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 155 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 72 references

Membrane transporters in drug development

Nature Reviews Drug Discovery • 2010
View 5 Excerpts
Highly Influenced

Physiological, pharmacological and pathological implications

D.E.Smith, B.Clemencon, M.A.Hediger. Proton-coupled oligopeptide transporter family SLC15
Mol Aspects Med. 34:323-336 • 2013
View 5 Excerpts
Highly Influenced

importance for pathophysiology and drug therapy

D.Keppler. Multidrug resistance proteins MRPs, ABCCs
Handb Exp Pharmacol:299-323 • 2011
View 6 Excerpts
Highly Influenced

Pharmaceutical and pharmacological importance of peptide transporters

M.Brandsch, I.Knutter, E.Bosse-Doenecke
J Pharm Pharmacol • 2008
View 10 Excerpts
Highly Influenced

Molecular characterization and inhibition of amanitin uptake into human hepatocytes

K.Letschert, H.Faulstich, D.Keller, D.Keppler
Toxicol Sci • 2006
View 6 Excerpts
Highly Influenced

a versatile efflux transporter for drugs and signalling molecules

F.G.Russel, J.B.Koenderink, R.Masereeuw. Multidrug resistance protein 4 MRP4ABCC4
Trends Pharmacol Sci. 29:200-207 • 2008
View 4 Excerpts
Highly Influenced

Structures of a Na+-coupled, substrate-bound MATE multidrug transporter

M.Lu, J.Symersky, +4 authors S.Koide
Proc Natl Acad Sci U S A • 2013
View 1 Excerpt