Emerging targeted therapies for melanoma treatment (Review)

@inproceedings{Russo2014EmergingTT,
  title={Emerging targeted therapies for melanoma treatment (Review)},
  author={Angela Russo and Bartolomea Ficili and Saverio Candido and Franca Maria Pezzino and Claudio Guarneri and Antonio Biondi and Salvatore Travali and James A McCubrey and Demetrios A. Spandidos and Massimo Libra},
  booktitle={International journal of oncology},
  year={2014}
}
Cutaneous melanoma is an aggressive cancer with a poor prognosis for patients with advanced disease. The identification of several key molecular pathways implicated in the pathogenesis of melanoma has led to the development of novel therapies for this devastating disease. In melanoma, both the Ras/Raf/MEK/ERK (MAPK) and the PI3K/AKT (AKT) signalling pathways are constitutively activated through multiple mechanisms. Targeting various effectors of these pathways with pharmacologic inhibitors may… CONTINUE READING
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