Emerging target-based paradigms to prevent and treat migraine.

@article{Silberstein2013EmergingTP,
  title={Emerging target-based paradigms to prevent and treat migraine.},
  author={Stephen David Silberstein},
  journal={Clinical pharmacology and therapeutics},
  year={2013},
  volume={93 1},
  pages={78-85}
}
Migraine is a primary brain disorder resulting from altered modulation of normal sensory stimuli and trigeminal nerve dysfunction. The second edition of the International Classification of Headache Disorders (ICHD-2) defines seven subtypes of migraine. Migraine treatment can be acute or preventive. New targeted therapies include 5-HT(1F) receptor agonists, calcitonin gene-related peptide (CGRP) antagonists, nitric oxide synthetase inhibitors, and ion channel antagonists. A recent development is… CONTINUE READING
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