Emerging structural insights into the function of ionotropic glutamate receptors.

  title={Emerging structural insights into the function of ionotropic glutamate receptors.},
  author={Erkan Karakas and Michael C. Regan and Hiro Furukawa},
  journal={Trends in biochemical sciences},
  volume={40 6},
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate excitatory neurotransmission crucial for brain development and function, including learning and memory formation. Recently a wealth of structural studies on iGluRs including AMPA receptors (AMPARs), kainate receptors, and NMDA receptors (NMDARs) became available. These studies showed structures of non-NMDARs including AMPAR and kainate receptor in various functional states, thereby providing the first visual… CONTINUE READING
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