Emerging structural explanations of ionotropic glutamate receptor function.

  title={Emerging structural explanations of ionotropic glutamate receptor function.},
  author={Robert L. McFeeters and Robert E. Oswald},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={18 3},
High-resolution studies of ionotropic glutamate receptor (iGluR) extracellular domains are beginning to bridge the gap between structure and function. Crystal structures have defined the ligand binding pocket well beyond what was suggested by mutational analysis and homology models alone, providing initial suggestions about the mechanisms of channel gating and desensitization. NMR-derived backbone dynamics and molecular dynamics simulations have added further insights into the role of protein… CONTINUE READING


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Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity

M. L. Lunn, A. Hogner, +3 authors J. S. Kastrup
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