Emerging senolytic agents derived from natural products

@article{Li2019EmergingSA,
  title={Emerging senolytic agents derived from natural products},
  author={Wen Li and Lin Qin and R. Feng and Guangrong Hu and Hui Sun and Yonghan He and Rongping Zhang},
  journal={Mechanisms of Ageing and Development},
  year={2019},
  volume={181},
  pages={1-6}
}
Cellular senescence is a hallmark of aging, it is a permanent state of cell cycle arrest induced by cellular stresses. During the aging process, senescent cells (SCs) increasingly accumulate in tissues, causing a loss of tissue-repair capacity because of cell cycle arrest in progenitor cells and produce proinflammatory and matrix-degrading molecules which are known as the senescence-associated secretory phenotype (SASP), and thereby contribute to the development of various age-related diseases… Expand
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