Emerging roles of ubiquitin in transcription regulation.

@article{Conaway2002EmergingRO,
  title={Emerging roles of ubiquitin in transcription regulation.},
  author={Ronald C. Conaway and Christopher S. Brower and Joan W Conaway},
  journal={Science},
  year={2002},
  volume={296 5571},
  pages={1254-8}
}
Ubiquitin is a small protein that was initially found to function as a tag that can be covalently attached to proteins to mark them for destruction by a multisubunit, adenosine 5'-triphosphate-dependent protease called the proteasome. Ubiquitin is now emerging as a key regulator of eukaryotic messenger RNA synthesis, a process that depends on the RNA synthetic enzyme RNA polymerase II and the transcription factors that control its activity. Ubiquitin controls messenger RNA synthesis not only by… CONTINUE READING

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