Emerging roles of tissue factor in viral hemorrhagic fever.

@article{Ruf2004EmergingRO,
  title={Emerging roles of tissue factor in viral hemorrhagic fever.},
  author={Wolfram Ruf},
  journal={Trends in immunology},
  year={2004},
  volume={25 9},
  pages={
          461-4
        }
}
Activation of coagulation by tissue factor (TF) is frequently observed in sepsis syndrome and is documented in certain viral hemorrhagic fevers. Coagulation protease complexes signal by activating the G-protein coupled, protease-activated receptors that regulate inflammation. Blockade of TF attenuates lethality in experimental models of Ebola virus infection but - similar to findings in bacterial sepsis - reduction of inflammation, rather than attenuation of coagulation, predicts survival of… CONTINUE READING
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