Emerging roles of the tumor-associated stroma in promoting tumor metastasis.

@article{Horimoto2012EmergingRO,
  title={Emerging roles of the tumor-associated stroma in promoting tumor metastasis.},
  author={Yoshiya Horimoto and Urszula M. Polanska and Yuko Takahashi and Akira Orimo},
  journal={Cell adhesion & migration},
  year={2012},
  volume={6 3},
  pages={
          193-202
        }
}
The stroma in human carcinomas consists of extracellular matrix and various types of non-carcinoma cells, mainly leukocytes, endothelial cells, fibroblasts, myofibroblasts and bone marrow-derived progenitors. The tumor-associated stroma actively supports tumor growth by stimulating neo-angiogenesis, as well as proliferation and invasion of apposed carcinoma cells. It has long been accepted that alterations within carcinoma cells mediate metastasis in a cell-autonomous fashion. Recent studies… CONTINUE READING

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