Emerging roles of the MAGE protein family in stress response pathways

  title={Emerging roles of the MAGE protein family in stress response pathways},
  author={Rebecca R Florke Gee and Helen H Chen and Anna K Lee and Christina A Daly and Benjamin A Wilander and Klementina Fon Tacer and P. Potts},
  journal={The Journal of Biological Chemistry},
  pages={16121 - 16155}
  • Rebecca R Florke Gee, Helen H Chen, +4 authors P. Potts
  • Published 2020
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • The melanoma antigen (MAGE) proteins all contain a MAGE homology domain. MAGE genes are conserved in all eukaryotes and have expanded from a single gene in lower eukaryotes to ∼40 genes in humans and mice. Whereas some MAGEs are ubiquitously expressed in tissues, others are expressed in only germ cells with aberrant reactivation in multiple cancers. Much of the initial research on MAGEs focused on exploiting their antigenicity and restricted expression pattern to target them with cancer… CONTINUE READING


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