Emerging roles of lymphatic endothelium in regulating adaptive immunity.

  title={Emerging roles of lymphatic endothelium in regulating adaptive immunity.},
  author={Catherine M. Card and Shann C. S. Yu and Melody A Swartz},
  journal={The Journal of clinical investigation},
  volume={124 3},
Emerging research on the roles of stromal cells in modulating adaptive immune responses has included a new focus on lymphatic endothelial cells (LECs). LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes. LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and… CONTINUE READING
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