Emerging roles of angiopoietin-like 4 in human cancer.

  title={Emerging roles of angiopoietin-like 4 in human cancer.},
  author={Ming Jie Tan and Ziqiang Teo and Ming Keat Sng and Pengcheng Zhu and Nguan Soon Tan},
  journal={Molecular cancer research : MCR},
  volume={10 6},
Angiopoietin-like 4 (ANGPTL4) is best known for its role as an adipokine involved in the regulation of lipid and glucose metabolism. The characterization of ANGPTL4 as an adipokine is largely due to our limited understanding of the interaction partners of ANGPTL4 and how ANGPTL4 initiates intracellular signaling. Recent findings have revealed a critical role for ANGPTL4 in cancer growth and progression, anoikis resistance, altered redox regulation, angiogenesis, and metastasis. Emerging… CONTINUE READING
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