Emerging roles of RETINOBLASTOMA-RELATED proteins in evolution and plant development.

@article{Gutzat2012EmergingRO,
  title={Emerging roles of RETINOBLASTOMA-RELATED proteins in evolution and plant development.},
  author={Ruben Gutzat and Lorenzo Borghi and Wilhelm Gruissem},
  journal={Trends in plant science},
  year={2012},
  volume={17 3},
  pages={139-48}
}
RETINOBLASTOMA-RELATED (RBR) proteins are plant homologs of the human tumor suppressor pRB. Similar to their animal counterparts they have roles in cell cycle regulation and differentiation. We discuss recent findings of the evolution of RBR functions ranging from a molecular ruler and metabolic integrator in algae to a coordinator of differentiation in gametophytes. Genetic analysis and manipulation of protein levels during gametophytic and post-embryonic plant development are now providing… CONTINUE READING
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