Emerging roles of NAD+ and its metabolites in cell signaling.

  title={Emerging roles of NAD+ and its metabolites in cell signaling.},
  author={Friedrich Koch-Nolte and Friedrich Erhard Haag and Andreas H. Guse and Frances Lund and Mathias Ziegler},
  journal={Science signaling},
  volume={2 57},
Nicotinamide adenine dinucleotide (NAD(+)) is the universal currency of energy metabolism and electron transfer. Recent studies indicate that apart from its role as a coenzyme, NAD(+) and its metabolites also function in cell signaling pathways; for example, they are substrates for nucleotide-metabolizing enzymes and ligands for extra- and intracellular receptors and ion channels. Moreover, the NAD(+) and NAD(+) phosphate metabolites adenosine 5'-diphosphoribose (ADP-ribose), cyclic ADP-ribose… CONTINUE READING


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