Emerging roles of E2Fs in cancer: an exit from cell cycle control

@article{Chen2009EmergingRO,
  title={Emerging roles of E2Fs in cancer: an exit from cell cycle control},
  author={Hui-Zi Chen and Shih-Yin Tsai and Gustavo Leone},
  journal={Nature Reviews Cancer},
  year={2009},
  volume={9},
  pages={785-797}
}
Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating the RB pathway have been identified in almost every human malignancy. The E2F transcription factors function in cell cycle control and are intimately regulated by RB. Studies of model organisms have revealed conserved functions for E2Fs during development, suggesting that the cancer-related proliferative roles of E2F family members represent a recent evolutionary adaptation. However, given that some human… CONTINUE READING
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