Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS

@article{Alexander2017EmergingRF,
  title={Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS},
  author={A. Alexander and A. Irving and J. Harvey},
  journal={Neuropharmacology},
  year={2017},
  volume={113},
  pages={652-660}
}
ABSTRACT Estrogens play a key role in regulating reproductive and neuroendocrine function by activating classical nuclear steroid receptors that act as ligand gated transcription factors. However evidence is growing that estrogens also promote rapid non‐genomic responses via activation of membrane‐associated estrogen receptors. The G protein‐coupled estrogen receptor (GPER1; also known as GPR30) has been identified as one of the main estrogen‐sensitive receptors responsible for the rapid non… Expand
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References

SHOWING 1-10 OF 190 REFERENCES
Mechanisms of estrogen signaling and gene expression via GPR30
  • 299
The G-protein-coupled estrogen receptor GPER in health and disease
  • 556
  • PDF
Virtual and biomolecular screening converge on a selective agonist for GPR30
  • 684
  • PDF
In vivo Effects of a GPR30 Antagonist
  • 402
GPR30 Does Not Mediate Estrogenic Responses in Reproductive Organs in Mice
  • 243
  • PDF
Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology.
  • 251
  • Highly Influential
  • PDF
...
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3
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5
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