Emerging roles for neogenin and its ligands in CNS development.

@article{Vries2008EmergingRF,
  title={Emerging roles for neogenin and its ligands in CNS development.},
  author={Melissa R de Vries and Helen M. Cooper},
  journal={Journal of neurochemistry},
  year={2008},
  volume={106 4},
  pages={
          1483-92
        }
}
  • Melissa R de Vries, Helen M. Cooper
  • Published in Journal of neurochemistry 2008
  • Medicine, Biology
  • It is now well established that the netrin guidance cues and their receptors comprise a major molecular guidance system driving axon pathfinding during nervous system development. One netrin receptor, neogenin, is now emerging as a key regulator of many developmental processes throughout the embryo. Unexpectedly, a new family of neogenin ligands, the repulsive guidance molecule (RGM) family, has recently been identified. The functional outcome of neogenin activation is dictated by both the… CONTINUE READING

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