Emerging role of the interleukin-8 cleaving enzyme SpyCEP in clinical Streptococcus pyogenes infection.

@article{Turner2009EmergingRO,
  title={Emerging role of the interleukin-8 cleaving enzyme SpyCEP in clinical Streptococcus pyogenes infection.},
  author={Claire E Turner and Prathiba Kurupati and Michael R. Jones and Robert J. Edwards and Shiranee Sriskandan},
  journal={The Journal of infectious diseases},
  year={2009},
  volume={200 4},
  pages={555-63}
}
Neutrophil chemoattractant interleukin (IL)-8 is cleaved and inactivated by the Streptococcus pyogenes cell envelope protease SpyCEP. A range of clinical S. pyogenes strains of differing emm type demonstrated SpyCEP activity, although transcription of the SpyCEP gene cepA differed 1000-fold between isolates. Disruption of the 2-component regulatory system covR/S in pharyngeal isolates increased cepA transcription 100-fold; this finding is consistent with endogenous CovR/S-mediated repression of… CONTINUE READING
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