Emerging role of the host restriction factor tetherin in viral immune sensing.

@article{Hotter2013EmergingRO,
  title={Emerging role of the host restriction factor tetherin in viral immune sensing.},
  author={Dominik Hotter and Daniel Sauter and Frank Kirchhoff},
  journal={Journal of molecular biology},
  year={2013},
  volume={425 24},
  pages={4956-64}
}
Tetherin (BST-2, CD317) is an interferon-inducible cellular factor that inhibits the release of diverse enveloped viruses by tethering them to the cell surface. Its importance in antiviral immunity is underscored by the observation that various viruses have evolved antagonists against this restriction factor. Accumulating evidence suggests that this is not only due to its ability to inhibit virus release but that tetherin also acts as an innate immune sensor of viral infections that activates… CONTINUE READING