Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology.

@article{Bouton2012EmergingRO,
  title={Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology.},
  author={M Bouton and Yacine Boulaftali and Benjamin Wakd Richard and V{\'e}ronique Arocas and Jean-Baptiste Michel and Martine Jandrot-Perrus},
  journal={Blood},
  year={2012},
  volume={119 11},
  pages={2452-7}
}
Serine protease inhibitors, termed serpins, are key regulators in many biologic events. Protease nexin-1 (PN-1) is a serpin that is barely detectable in plasma but found in many organs and produced by most cell types, including monocytes, platelets, and vascular cells. It has a large inhibition spectrum because it is the most efficient tissue inhibitor of thrombin but also a powerful inhibitor of plasminogen activators and plasmin. It has a high affinity for glycosaminoglycans, such as heparan… CONTINUE READING

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