Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia.

  title={Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia.},
  author={Adrian Wiestner},
  volume={120 24},
Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells that depend on host factors in the tissue microenvironment for survival and proliferation. In vitro, CLL cells rapidly undergo apoptosis unless microenvironmental factors are provided that support their survival. Signaling pathways activated in the microenvironment in vivo include the B-cell receptor (BCR) and NF-κB pathways. Thus, CLL is a disease "addicted to the host" and is dependent on pathways that promote normal B-cell… CONTINUE READING
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