Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases.

@article{Kadota2017EmergingRO,
  title={Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases.},
  author={Tsukasa Kadota and Yu Fujita and Yusuke Yoshioka and Jun Araya and Kazuyoshi Kuwano and Takahiro Ochiya},
  journal={Molecular aspects of medicine},
  year={2017},
  volume={60},
  pages={
          92-103
        }
}
Aging is a major risk factor for the development of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. A main aspect of aging is the impaired function of maintaining homeostasis in the organs and body, which is associated with cellular senescence. Cellular senescence is recognized as the state of irreversible cell cycle arrest in response to a variety of cellular stresses. Senescent cells are not simply cell cycle… CONTINUE READING
4
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Exosomes as Emerging Pro-Tumorigenic Mediators of the Senescence-Associated Secretory Phenotype

  • International journal of molecular sciences
  • 2019
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 170 REFERENCES

Extracellular vesicles: Exosomes, microvesicles, and friends

  • The Journal of cell biology
  • 2013
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Exosome cargo re fl ects TGF - b 1 - mediated epithelial - to - mesenchymal transition ( EMT ) status in A 549 human lung adenocarcinoma cells

N. Kosaka, H. Iguchi, T. Ochiya
  • Biochem . Biophys . Res . Commun .
  • 2010
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

Proin fl ammatory role of epithelial cell - derived exosomes in allergic airway in fl ammation

M. Kumar, W. Seeger, R. Voswinckel
  • J . Allergy Clin . Immunol .
  • 2014
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Autophagy and exosomes

A. L. j.cell.2007.12.032. Wang, T. J. Lukas, M. Yuan, N. Du, M. O. Tso
  • 2009
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL