Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease.

@article{Aleksunes2007EmergingRO,
  title={Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease.},
  author={Lauren M. Aleksunes and Jos{\'e} Enrique Manautou},
  journal={Toxicologic pathology},
  year={2007},
  volume={35 4},
  pages={459-73}
}
Transcription factor NF-E2-related factor 2 (Nrf2) belongs to the basic region-leucine zipper family and is activated in response to electrophiles and reactive oxygen species. Nrf2 coordinately regulates the constitutive and inducible transcription of a wide array of genes involved in drug metabolism, detoxification, and antioxidant defenses. During periods of oxidative stress, Nrf2 is released from sequestration in the cytoplasm and translocates to the nucleus. Nrf2 binds antioxidant response… CONTINUE READING

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