Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)

@inproceedings{Li2015EmergingRO,
  title={Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)},
  author={Jun Li and Lin Ye and Sioned Owen and Hoi Ping Weeks and Zhongtao Zhang and Wen Jiang},
  booktitle={International journal of molecular medicine},
  year={2015}
}
The CCN family of proteins comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6. They share four evolutionarily conserved functional domains, and usually interact with various cytokines to elicit different biological functions including cell proliferation, adhesion, invasion, migration, embryonic development, angiogenesis, wound healing, fibrosis and inflammation through a variety of signalling pathways. In the past two decades, emerging functions for the CCN proteins (CCNs) have been… CONTINUE READING