Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis.

  title={Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis.},
  author={Arnaud Autret and Seamus J. Martin},
  journal={Molecular cell},
  volume={36 3},
Bcl-2 family proteins regulate apoptosis by controlling the release of mitochondrial cytochrome c via the Bax/Bak channel. However, recent studies have also implicated several members of this family in the regulation of mitochondrial fission/fusion dynamics. It has been debated whether the role of Bcl-2 proteins in mitochondrial morphogenesis is functionally distinct from their role in apoptosis, with some arguing that Bax/Bak-induced mitochondrial fission promotes apoptosis-associated… CONTINUE READING

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transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

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