Emerging pulmonary vasculature lacks fate specification.

  title={Emerging pulmonary vasculature lacks fate specification.},
  author={Margaret A Schwarz and Lauren Caldwell and Danielle E. Cafasso and Haihua Zheng},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={296 1},
Lung morphogenesis requires precise coordination between branching morphogenesis and vascularization to generate distal airways capable of supporting respiration at the cell-cell interface. The specific origins and types of blood vessels that initially form in the lung, however, remain obscure. Herein, we definitively show that during the early phases of lung development [i.e., embryonic day (E) 11.5], functional vessels, replete with blood flow, are restricted to the mesenchyme, distal to the… CONTINUE READING
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