Emerging principles in protease-based drug discovery

@article{Drg2010EmergingPI,
  title={Emerging principles in protease-based drug discovery},
  author={Marcin Drąg and Guy Salvesen},
  journal={Nature Reviews Drug Discovery},
  year={2010},
  volume={9},
  pages={690-701}
}
Proteases have an important role in many signalling pathways, and represent potential drug targets for diseases ranging from cardiovascular disorders to cancer, as well as for combating many parasites and viruses. Although inhibitors of well-established protease targets such as angiotensin-converting enzyme and HIV protease have shown substantial therapeutic success, developing drugs for new protease targets has proved challenging in recent years. This in part could be due to issues such as the… CONTINUE READING
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