Emerging opportunities for allosteric modulation of G-protein coupled receptors.

@article{Wang2013EmergingOF,
  title={Emerging opportunities for allosteric modulation of G-protein coupled receptors.},
  author={Ching-I. A. Wang and Richard James Lewis},
  journal={Biochemical pharmacology},
  year={2013},
  volume={85 2},
  pages={
          153-62
        }
}
Their ubiquitous nature, wide cellular distribution and versatile molecular recognition and signalling help make G-protein binding receptors (GPCRs) the most important class of membrane proteins in clinical medicine, accounting for ∼40% of all current therapeutics. A large percentage of current drugs target the endogenous ligand binding (orthosteric) site, which are structurally and evolutionarily conserved, particularly among members of the same GPCR subfamily. With the recent advances in GPCR… CONTINUE READING
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