Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes.

@article{Wong2013EmergingNF,
  title={Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes.},
  author={Brian W Wong and Anna Kuchnio and Ulrike Bruning and Peter Carmeliet},
  journal={Trends in biochemical sciences},
  year={2013},
  volume={38 1},
  pages={3-11}
}
Oxygen-sensing prolyl hydroxylase domain enzymes (PHDs) target hypoxia-inducible factor (HIF)-α subunits for proteasomal degradation in normoxia through hydroxylation. Recently, novel mechanisms of PHD activation and function have been unveiled. Interestingly, PHD3 can unexpectedly amplify HIF signaling through hydroxylation of the glycolytic enzyme pyruvate kinase (PK) muscle isoform 2 (PKM2). Recent studies have also yielded insight into HIF-independent PHD functions, including the control of… CONTINUE READING
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