Emerging landscape of oncogenic signatures across human cancers

@inproceedings{Ciriello2013EmergingLO,
  title={Emerging landscape of oncogenic signatures across human cancers},
  author={Giovanni Ciriello and Martin L. Miller and B{\"u}lent Arman Aksoy and Yasin Şenbabaoğlu and Nikolaus Schultz and Chris Sander},
  booktitle={Nature Genetics},
  year={2013}
}
Cancer therapy is challenged by the diversity of molecular implementations of oncogenic processes and by the resulting variation in therapeutic responses. Projects such as The Cancer Genome Atlas (TCGA) provide molecular tumor maps in unprecedented detail. The interpretation of these maps remains a major challenge. Here we distilled thousands of genetic and epigenetic features altered in cancers to ∼500 selected functional events (SFEs). Using this simplified description, we derived a… CONTINUE READING
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