Emerging innovations in clinical trial design.

  title={Emerging innovations in clinical trial design.},
  author={Donald A. Berry},
  journal={Clinical pharmacology and therapeutics},
  volume={99 1},
Designs of clinical trials have changed little since the advent of randomization in the 1940s. Modern innovations in designs are being driven by the increasing recognition in clinical research that diseases are heterogeneous and patients who apparently have the same disease require different therapies. This article describes some innovations in clinical… CONTINUE READING