Emerging immunological targets in inflammatory bowel disease.

  title={Emerging immunological targets in inflammatory bowel disease.},
  author={Giovanni Monteleone and Francesco Pallone and Thomas Macdonald},
  journal={Current opinion in pharmacology},
  volume={11 6},
Crohn's disease (CD) and ulcerative colitis (UC) are the major forms of inflammatory bowel diseases (IBD) in man. They are caused by damage to the lining of the intestine and deeper layers, due to an excessive immune response directed against components of the gut microflora and poorly controlled by counter-regulatory mechanisms. CD and UC are however immunologically distinct. CD-related inflammation is characterized by a marked mucosal infiltration of T lymphocytes secreting T helper type (Th… CONTINUE READING


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