Emerging functions of the unfolded protein response in immunity

  title={Emerging functions of the unfolded protein response in immunity},
  author={Sophie Janssens and Bali Pulendran and Bart M. Lambrecht},
  journal={Nature Immunology},
The unfolded protein response (UPR) has traditionally been viewed as an adaptive response triggered by the accumulation of unfolded proteins in the endoplasmic reticulum (ER) and aimed at restoring ER function. The UPR can also be an anticipatory response that is activated well before the disruption of protein homeostasis. UPR signaling intersects at many levels with the innate and adaptive immune responses. In some types of cells of the immune system, such as dendritic cells (DCs) and B cells… CONTINUE READING
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