Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

  title={Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system},
  author={Hemmo Meyer and Monika Bug and Sebastian Bremer},
  journal={Nature Cell Biology},
The ATP-driven chaperone valosin-containing protein (VCP)/p97 governs critical steps in ubiquitin-dependent protein quality control and intracellular signalling pathways. It cooperates with diverse partner proteins to help process ubiquitin-labelled proteins for recycling or degradation by the proteasome in many cellular contexts. Recent studies have uncovered unexpected cellular functions for p97 in autophagy, endosomal sorting and regulating protein degradation at the outer mitochondrial… CONTINUE READING
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