Emerging functions of alternative splicing coupled with nonsense-mediated decay.

@article{Hamid2014EmergingFO,
  title={Emerging functions of alternative splicing coupled with nonsense-mediated decay.},
  author={Fursham M. Hamid and Eugene V Makeyev},
  journal={Biochemical Society transactions},
  year={2014},
  volume={42 4},
  pages={1168-73}
}
Higher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. An important example of the latter function involves an interplay between AS and NMD (nonsense-mediated decay), a cytoplasmic quality control mechanism eliminating mRNAs containing PTCs (premature translation termination codons). Although originally identified as an error surveillance process… CONTINUE READING