Emerging functions of BRCA2 in DNA recombination.

  title={Emerging functions of BRCA2 in DNA recombination.},
  author={Luca Pellegrini and Ashok R. Venkitaraman},
  journal={Trends in biochemical sciences},
  volume={29 6},
Mutations in the breast cancer susceptibility protein BRCA2 cause inherited susceptibility to breast, ovarian and other cancers. There is now compelling experimental evidence that a major biological function of BRCA2 is the maintenance of chromosome structure stability in dividing cells by regulation of steps in recombination between homologous DNA strands. Recent experimental findings shape the current models for BRCA2 function, and structural and biochemical advances shed new light on the… CONTINUE READING

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