Emerging evolutionary paradigms in antibiotic discovery

@article{Chevrette2018EmergingEP,
  title={Emerging evolutionary paradigms in antibiotic discovery},
  author={Marc G. Chevrette and Cameron R. Currie},
  journal={Journal of Industrial Microbiology \& Biotechnology},
  year={2018},
  volume={46},
  pages={257-271}
}
Antibiotics revolutionized medicine and remain its cornerstone. Despite their global importance and the continuous threat of resistant pathogens, few antibiotics have been discovered in recent years. Natural products, especially the secondary metabolites of Actinobacteria, have been the traditional discovery source of antibiotics. In nature, the chemistry of antibiotic natural products is shaped by the unique evolution and ecology of their producing organisms, yet these influences remain… Expand
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