Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways.

Abstract

There are eight members of the phosphoinositide family of phospholipids in eukaryotes; PI, PI3P, PI4P, PI5P, PI(4,5)P2, PI(3,4)P2, PI(3,5)P2 and PI(3,4,5)P3. Receptor activation of Class I PI3Ks stimulates the phosphorylation of PI(4,5)P2 to form PI(3,4,5)P3. PI(3,4,5)P3 is an important messenger molecule that is part of a complex signalling network… (More)
DOI: 10.1042/BST20150248

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Cite this paper

@article{Hawkins2016EmergingEO, title={Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways.}, author={Phillip T. Hawkins and Len R. Stephens}, journal={Biochemical Society transactions}, year={2016}, volume={44 1}, pages={307-14} }