Emerging drugs for the treatment of tobacco dependence: 2014 update

@article{Elrashidi2014EmergingDF,
  title={Emerging drugs for the treatment of tobacco dependence: 2014 update},
  author={Muhamad Elrashidi and J. Ebbert},
  journal={Expert Opinion on Emerging Drugs},
  year={2014},
  volume={19},
  pages={243 - 260}
}
Introduction: Tobacco dependence remains a global epidemic and the largest preventable cause of morbidity and mortality around the world. Smoking cessation has benefits at all ages but remains challenging for several reasons, among which are the complexities of nicotine addiction and limitations of available pharmacotherapies. Areas covered: This review summarizes current and emerging pharmacotherapies for the treatment of tobacco dependence, including first- and second-line recommended agents… Expand
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References

SHOWING 1-10 OF 164 REFERENCES
Emerging drugs for the treatment of tobacco dependence
TLDR
Varenicline, an α4β2 nAChR partial agonist, is an emerging drug therapy that modifies tobacco use behavior by acting directly on nicotine receptors in the reward centers of the central nervous system. Expand
Developments in pharmacotherapy for tobacco dependence: past, present and future.
TLDR
There is a need for studies designed to evaluate the efficacy of pharmacotherapies in populations such as youth, pregnant smokers and smokers with co-occurring mental health problems, and for long-term combination pharmacotherapy combined with improved psychosocial support to enhance medication compliance. Expand
Adverse Effects and Tolerability of Medications for the Treatment of Tobacco Use and Dependence
TLDR
The benefit: risk ratio is strongly in favour of pharmacotherapy for tobacco dependence treatment in virtually all smokers who are motivated to quit, and the risks of continued tobacco use and the benefits of treatment are strong. Expand
Varenicline and combination nicotine replacement therapy are the most effective pharmacotherapies for treating tobacco use
TLDR
An overview and network meta-analysis of pharmacological interventions for smoking cessation and their comparative efficacies and risks are conducted to help guide treatment, policy and future research. Expand
Pharmacotherapy for Treating Tobacco Dependence
TLDR
The aim of this review is to present the current evidence supporting the notion that long-term therapy for treating tobacco dependence may be appropriately considered for some tobacco users. Expand
Clinical Strategies to Enhance the Efficacy of Nicotine Replacement Therapy for Smoking Cessation: A Review of the Literature
TLDR
A literature review examines emerging clinical strategies to improve NRT efficacy and a brief discussion of emergent NRT products, which may ultimately offer greater efficacy than current formulations. Expand
Pharmacological interventions for smoking cessation: an overview and network meta-analysis.
TLDR
The outcome for benefit is continuous or prolonged abstinence at least six months from the start of treatment, and the outcome for harms is the incidence of serious adverse events associated with each of the treatments. Expand
Neuronal Mechanisms Underlying Development of Nicotine Dependence: Implications for Novel Smoking-Cessation Treatments
TLDR
The neural substrates, especially nicotinic acetylcholine receptors, that mediate the reinforcing effects of nicotine and the development of nicotine dependence are focused on. Expand
Healthcare financing systems for increasing the use of tobacco dependence treatment.
TLDR
There is some evidence that healthcare financing systems directed at smokers which offer a full financial benefit can increase the self-reported prolonged abstinence rates at relatively low costs when compared with a partial or no benefit. Expand
Recent advances in the pharmacotherapy of smoking.
TLDR
It is concluded that pharmacotherapy should be made available to all smokers, because all currently available therapies appear to be equally efficacious, approximately doubling the quit rate compared with placebo. Expand
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